Summary of previous matches between the team of Manchester United and the team of Southampton since 2003-08-31:
Manchester United won 18 matches against Southampton, lost 3 matches, and 10 matches were draws.
| Time | League | Home Team | Score | Away Team |
|---|---|---|---|---|
| 2022-08-07 | English Premier League | Manchester United | 1 : 2 | Brighton Hove Albion |
| 2022-07-31 | International Club Friendly | Manchester United | 1 : 1 | Rayo Vallecano |
| 2022-07-30 | International Club Friendly | Atletico Madrid | 1 : 0 | Manchester United |
| 2022-07-23 | International Club Friendly | Manchester United | 2 : 2 | Aston Villa |
| 2022-07-19 | International Club Friendly | Manchester United | 3 : 1 | Crystal Palace |
| 2022-07-15 | International Club Friendly | Melbourne Victory | 1 : 4 | Manchester United |
| 2022-07-12 | International Club Friendly | Manchester United | 4 : 0 | Liverpool |
| 2022-05-22 | English Premier League | Crystal Palace | 1 : 0 | Manchester United |
| 2022-05-08 | English Premier League | Brighton Hove Albion | 4 : 0 | Manchester United |
| 2022-05-03 | English Premier League | Manchester United | 3 : 0 | Brentford |
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